Hiroyuki Kugoh Selected Research

Neoplasms (Cancer)

1/2023	Human artificial chromosome carrying 3p21.3-p22.2 region suppresses hTERT transcription in oral cancer cells.
3/2022	Activation of PPARγ in bladder cancer via introduction of the long arm of human chromosome 9.
1/2022	MTA1, a metastasis‑associated protein, in endothelial cells is an essential molecule for angiogenesis.
1/2021	Human chromosome 3p21.3 carries TERT transcriptional regulators in pancreatic cancer.
1/2019	PITX1 protein interacts with ZCCHC10 to regulate hTERT mRNA transcription.
12/2015	Studies of Tumor Suppressor Genes via Chromosome Engineering.
2/2015	miR-19b regulates hTERT mRNA expression through targeting PITX1 mRNA in melanoma cells.
4/2011	Identification of PITX1 as a TERT suppressor gene located on human chromosome 5.
7/2008	CTCFL/BORIS is a methylation-independent DNA-binding protein that preferentially binds to the paternal H19 differentially methylated region.
1/2003	Human chromosome 5 carries a putative telomerase repressor gene.

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Hiroyuki Kugoh Research Topics

Disease

12	Neoplasms (Cancer) 01/2023 - 03/2002
4	Colorectal Neoplasms (Colorectal Cancer) 01/2022 - 11/2006
2	Melanoma (Melanoma, Malignant) 01/2021 - 02/2015
2	Squamous Cell Carcinoma of Head and Neck 07/2016 - 03/2014
2	Carcinogenesis 05/2010 - 07/2002
2	Tuberous Sclerosis (Bourneville's Disease) 07/2002 - 03/2002
1	Urinary Bladder Neoplasms (Bladder Cancer) 03/2022
1	Neoplasm Metastasis (Metastasis) 01/2022
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021
1	Fragile X Tremor Ataxia Syndrome 01/2021
1	Ataxia (Dyssynergia) 01/2021
1	Tremor (Tremors) 01/2021
1	Renal Cell Carcinoma (Grawitz Tumor) 01/2017
1	Hypoxia (Hypoxemia) 04/2012
1	X-Linked Combined Immunodeficiency Diseases (X Linked Severe Combined Immunodeficiency) 05/2006
1	Carcinoma (Carcinomatosis) 11/2005
1	Lipoma (Lipomata) 07/2002
1	Leiomyoma (Uterine Fibroids) 07/2002
1	Hamartoma 07/2002
1	Polycystic Kidney Diseases (Polycystic Kidney Disease) 03/2002
1	Autosomal Dominant Polycystic Kidney (ADPKD) 03/2002

Drug/Important Bio-Agent (IBA)

6	Telomerase (Telomerase Reverse Transcriptase)IBA 01/2021 - 01/2003
5	Proteins (Proteins, Gene)FDA Link 01/2021 - 03/2002
3	Messenger RNA (mRNA)IBA 01/2023 - 02/2015
3	EnzymesIBA 01/2019 - 01/2003
2	Long Noncoding RNAIBA 01/2021 - 02/2016
2	CateninsIBA 02/2016 - 03/2002
2	RibonucleoproteinsIBA 04/2011 - 01/2003
2	DNA (Deoxyribonucleic Acid)IBA 07/2008 - 07/2002
1	Phenobarbital (Luminal)FDA Link 03/2022
1	Monoclonal AntibodiesIBA 01/2022
1	homeobox protein PITX1IBA 01/2021
1	AcidsIBA 01/2021
1	Transcription Factors (Transcription Factor)IBA 01/2021
1	protoporphyrin IXIBA 01/2021
1	Untranslated RNA (Noncoding RNA)IBA 01/2021
1	SOX Transcription FactorsIBA 01/2021
1	MicroRNAs (MicroRNA)IBA 01/2017
1	Sunitinib (Sutent)FDA Link 01/2017
1	Biomarkers (Surrogate Marker)IBA 07/2016
1	MutS ProteinsIBA 04/2012
1	Small Interfering RNA (siRNA)IBA 04/2012
1	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 04/2012
1	RNA (Ribonucleic Acid)IBA 11/2006
1	Cytokine Receptors (Cytokine Receptor)IBA 05/2006
1	NestinIBA 11/2005
1	HMGA ProteinsIBA 07/2002
1	HMGA2 ProteinIBA 07/2002
1	Cadherins (E-Cadherin)IBA 03/2002
1	trans-sodium crocetinate (crocetin)IBA 03/2002
1	Tuberous Sclerosis Complex 2 ProteinIBA 03/2002
1	Membrane Proteins (Integral Membrane Proteins)IBA 03/2002

Therapy/Procedure

1	Therapeutics 01/2022
1	Drug Therapy (Chemotherapy) 07/2016
1	Biological Therapy 12/2015